Publications & Preprints
See my Google Scholar page for an up-to-date list of publications.
*denotes equal contribution
^denotes mentored undergraduate
Preprints
Martinez i Zurita, A, Kyriazis, CC & KE Lohmueller. 2024. The impact of non-neutral synonymous mutations when inferring selection on non-synonymous mutations. bioRxiv. https://doi.org/10.1101/2024.02.07.579314
2024
Kyriazis, CC & KE Lohmueller. 2024 Constraining models of dominance for nonsynonymous mutations in the human genome. PLoS Genetics, 20: e1011198. https://doi.org/10.1371/journal.pgen.1011198
Kyriazis, CC, Serieys, LEK, Bishop, JM, Drouilly, M, Viljoen, S, Wayne, RK & KE Lohmueller. 2024. The influence of gene flow on population viability in an isolated urban caracal population. Molecular Ecology, 33:1-20. https://doi.org/10.1111/mec.17346 [pdf]
2023
Kyriazis, CC, Robinson, JA, & KE Lohmueller. 2023. Using computational simulations to model deleterious variation and genetic load in natural populations. American Naturalist, 202:737-752. https://doi.org/10.1086/726736 [pdf]
Nigenda-Morales, SF*, Lin, M*, Nuñez-Valencia, PG, Kyriazis, CC, Beichman, AC, Robinson, JA, Ragsdale, AP, Urbán, J, Archer, FI, Viloria-Gómora, L, Pérez-Álvarez, MJ, Poulin, E, Lohmueller, KE, Moreno-Estrada, A & RK Wayne. 2023. The genomic footprint of whaling and isolation in fin whale populations. Nature Communications, 14:5465. https://doi.org/10.1038/s41467-023-40052-z [pdf]
Wade, EE*^, Kyriazis, CC*, Cavassim, MIA* & KE Lohmueller. 2023. Quantifying the fraction of new mutations that are recessive lethal. Evolution, 77:1539-1549. https://doi.org/10.1093/evolut/qpad061 [pdf]
Digest: Few mutations are recessive lethal
Kyriazis, CC, Robinson, JA, Nigenda-Morales, SF, Beichman, AB, Rojas-Bracho, L, Fontaine, M, Robertson, KM, Wayne, RK, Lohmueller, KE, Taylor, BL, & PA Morin. 2023. Models based on best-available information support a low inbreeding load and potential for recovery in the vaquita. Heredity, 130:183-187. https://doi.org/10.1038/s41437-023-00608-7 [pdf]
Kyriazis, CC, Beichman, AB, Brzeski, KE, Hoy, SR, Peterson, RO, Vucetch, JA, Vucetch, LM, Lohmueller, KE & RK Wayne. 2023. Genomic underpinnings of population persistence in Isle Royale moose. Molecular Biology and Evolution, 40, 1-17. https://doi.org/10.1093/molbev/msad021 [pdf]
Robinson, JA, Kyriazis, CC, Yuan, SC, & KE Lohmueller. 2023. Deleterious Variation in Natural Populations and Implications for Conservation Genetics. Annual Reviews of Animal Biosciences, 11, 93-114. https://doi.org/10.1146/annurev-animal-080522-093311 [pdf]
Beichman, AC, Kalhori, P, Kyriazis, CC, DeVries, AA, Nigenda-Morales, S, Koepfli, K, Heckel, G, Schramm, Y, Moreno-Estrada, A, Kennett, DJ, Hylkema, M, Bodkin, J, Lohmueller, KE, & RK Wayne. 2023. Genomic analyses reveal range-wide devastation of sea otter populations. Molecular Ecology, 32, 281-298. https://doi.org/10.1111/mec.16334 [pdf]
2022
Exposito-Alonso, M, Booker, TA, Czech, L, Fukami, T, Gillespie, L, Hateley, S, Kyriazis, CC, Lang, PLM, Leventhal, L, Nogues-Bravo, D, Pagowski, V, Ruffley, M, Spence, JP, Toro Arana, SE, Weiß, CL, & E Zess. 2022. Genetic diversity loss in the Anthropocene. Science, 377, 1431–1435. DOI: 10.1126/science.abn5642 [pdf]
Robinson, JA*, Kyriazis, CC*, Nigenda-Morales, SF, Beichman, AB, Rojas-Bracho, L, Fontaine, M, Robertson, KM, Wayne, RK, Lohmueller, KE, Taylor, BL, & PA Morin. 2022. The critically endangered vaquita is not doomed to extinction by inbreeding depression. Science, 376, 635-639. DOI: 10.1126/science.abm1742 [pdf]
Media coverage: CNN, NPR, NYT, Washington Post, National Geographic, BBC, CBC, Reuters, The Guardian, Gizmodo, New Scientist, Ars Technica
2021
Kyriazis, CC, Wayne, RK, & KE Lohmueller. 2021. Strongly deleterious mutations are a primary determinant of extinction risk due to inbreeding depression. Evolution Letters, 5, 33-47. https://doi.org/10.1002/evl3.209 [pdf]
Media coverage: The Atlantic, Science Magazine
2020
Adrion, JR*, Cole, CB*, Dukler, ND*, Galloway, JG*, Gladstein, AL*, Gower, G*, Kyriazis, CC*, Ragsdale, AR*, Tsambos, G*, Baumdicker, F, Carlson, J, Cartwright, RA, Durvasula, A, Gronau, I, Kim, BY, McKenzie, P, Messer, PW, Noskova, E, Ortega-Del Vecchyo, D, Racimo, F, Struck, TJ, Gravel, S, Gutenkunst, RN, Lohmueller, KE, Ralph, PL, Schrider, DR, Siepel, A, Kelleher, J, & AD Kern. 2020. A community-maintained standard library of population genetic models. eLife, 9:e54967. https://doi.org/10.7554/eLife.54967 [pdf]
Media coverage: Nature Methods
pre-2019
Heaney, LR*, Kyriazis, CC*, Balete, DS, Rickart, EA & SJ Steppan. 2018. How small an island? Speciation by endemic mammals on an oceanic Philippine island. Journal of Biogeography, 45, 1675-1687. [pdf]
Media coverage: Science Magazine, Nature, Mongabay
Kyriazis, CC, Alam, B, Wjodyla, M, Hosner, PA, Hackett, SJ, Mays Jr., HL., Heaney, LR & S Reddy. 2018. Colonization and diversification of the White-browed Shortwing in the Philippines. Molecular Phylogenetics and Evolution, 121, 121-131. [pdf]
Kyriazis, CC, Bates, JM & LR Heaney. 2017. Dynamics of genetic and morphological diversification in an incipient intra-island radiation of Philippine rodents (Muridae: Bullimus). Journal of Biogeography, 44, 2585-2594.
*denotes equal contribution
^denotes mentored undergraduate
Preprints
Martinez i Zurita, A, Kyriazis, CC & KE Lohmueller. 2024. The impact of non-neutral synonymous mutations when inferring selection on non-synonymous mutations. bioRxiv. https://doi.org/10.1101/2024.02.07.579314
2024
Kyriazis, CC & KE Lohmueller. 2024 Constraining models of dominance for nonsynonymous mutations in the human genome. PLoS Genetics, 20: e1011198. https://doi.org/10.1371/journal.pgen.1011198
Kyriazis, CC, Serieys, LEK, Bishop, JM, Drouilly, M, Viljoen, S, Wayne, RK & KE Lohmueller. 2024. The influence of gene flow on population viability in an isolated urban caracal population. Molecular Ecology, 33:1-20. https://doi.org/10.1111/mec.17346 [pdf]
2023
Kyriazis, CC, Robinson, JA, & KE Lohmueller. 2023. Using computational simulations to model deleterious variation and genetic load in natural populations. American Naturalist, 202:737-752. https://doi.org/10.1086/726736 [pdf]
Nigenda-Morales, SF*, Lin, M*, Nuñez-Valencia, PG, Kyriazis, CC, Beichman, AC, Robinson, JA, Ragsdale, AP, Urbán, J, Archer, FI, Viloria-Gómora, L, Pérez-Álvarez, MJ, Poulin, E, Lohmueller, KE, Moreno-Estrada, A & RK Wayne. 2023. The genomic footprint of whaling and isolation in fin whale populations. Nature Communications, 14:5465. https://doi.org/10.1038/s41467-023-40052-z [pdf]
Wade, EE*^, Kyriazis, CC*, Cavassim, MIA* & KE Lohmueller. 2023. Quantifying the fraction of new mutations that are recessive lethal. Evolution, 77:1539-1549. https://doi.org/10.1093/evolut/qpad061 [pdf]
Digest: Few mutations are recessive lethal
Kyriazis, CC, Robinson, JA, Nigenda-Morales, SF, Beichman, AB, Rojas-Bracho, L, Fontaine, M, Robertson, KM, Wayne, RK, Lohmueller, KE, Taylor, BL, & PA Morin. 2023. Models based on best-available information support a low inbreeding load and potential for recovery in the vaquita. Heredity, 130:183-187. https://doi.org/10.1038/s41437-023-00608-7 [pdf]
Kyriazis, CC, Beichman, AB, Brzeski, KE, Hoy, SR, Peterson, RO, Vucetch, JA, Vucetch, LM, Lohmueller, KE & RK Wayne. 2023. Genomic underpinnings of population persistence in Isle Royale moose. Molecular Biology and Evolution, 40, 1-17. https://doi.org/10.1093/molbev/msad021 [pdf]
Robinson, JA, Kyriazis, CC, Yuan, SC, & KE Lohmueller. 2023. Deleterious Variation in Natural Populations and Implications for Conservation Genetics. Annual Reviews of Animal Biosciences, 11, 93-114. https://doi.org/10.1146/annurev-animal-080522-093311 [pdf]
Beichman, AC, Kalhori, P, Kyriazis, CC, DeVries, AA, Nigenda-Morales, S, Koepfli, K, Heckel, G, Schramm, Y, Moreno-Estrada, A, Kennett, DJ, Hylkema, M, Bodkin, J, Lohmueller, KE, & RK Wayne. 2023. Genomic analyses reveal range-wide devastation of sea otter populations. Molecular Ecology, 32, 281-298. https://doi.org/10.1111/mec.16334 [pdf]
2022
Exposito-Alonso, M, Booker, TA, Czech, L, Fukami, T, Gillespie, L, Hateley, S, Kyriazis, CC, Lang, PLM, Leventhal, L, Nogues-Bravo, D, Pagowski, V, Ruffley, M, Spence, JP, Toro Arana, SE, Weiß, CL, & E Zess. 2022. Genetic diversity loss in the Anthropocene. Science, 377, 1431–1435. DOI: 10.1126/science.abn5642 [pdf]
Robinson, JA*, Kyriazis, CC*, Nigenda-Morales, SF, Beichman, AB, Rojas-Bracho, L, Fontaine, M, Robertson, KM, Wayne, RK, Lohmueller, KE, Taylor, BL, & PA Morin. 2022. The critically endangered vaquita is not doomed to extinction by inbreeding depression. Science, 376, 635-639. DOI: 10.1126/science.abm1742 [pdf]
Media coverage: CNN, NPR, NYT, Washington Post, National Geographic, BBC, CBC, Reuters, The Guardian, Gizmodo, New Scientist, Ars Technica
2021
Kyriazis, CC, Wayne, RK, & KE Lohmueller. 2021. Strongly deleterious mutations are a primary determinant of extinction risk due to inbreeding depression. Evolution Letters, 5, 33-47. https://doi.org/10.1002/evl3.209 [pdf]
Media coverage: The Atlantic, Science Magazine
2020
Adrion, JR*, Cole, CB*, Dukler, ND*, Galloway, JG*, Gladstein, AL*, Gower, G*, Kyriazis, CC*, Ragsdale, AR*, Tsambos, G*, Baumdicker, F, Carlson, J, Cartwright, RA, Durvasula, A, Gronau, I, Kim, BY, McKenzie, P, Messer, PW, Noskova, E, Ortega-Del Vecchyo, D, Racimo, F, Struck, TJ, Gravel, S, Gutenkunst, RN, Lohmueller, KE, Ralph, PL, Schrider, DR, Siepel, A, Kelleher, J, & AD Kern. 2020. A community-maintained standard library of population genetic models. eLife, 9:e54967. https://doi.org/10.7554/eLife.54967 [pdf]
Media coverage: Nature Methods
pre-2019
Heaney, LR*, Kyriazis, CC*, Balete, DS, Rickart, EA & SJ Steppan. 2018. How small an island? Speciation by endemic mammals on an oceanic Philippine island. Journal of Biogeography, 45, 1675-1687. [pdf]
Media coverage: Science Magazine, Nature, Mongabay
Kyriazis, CC, Alam, B, Wjodyla, M, Hosner, PA, Hackett, SJ, Mays Jr., HL., Heaney, LR & S Reddy. 2018. Colonization and diversification of the White-browed Shortwing in the Philippines. Molecular Phylogenetics and Evolution, 121, 121-131. [pdf]
Kyriazis, CC, Bates, JM & LR Heaney. 2017. Dynamics of genetic and morphological diversification in an incipient intra-island radiation of Philippine rodents (Muridae: Bullimus). Journal of Biogeography, 44, 2585-2594.