Publications & Preprints
See my Google Scholar page for an up-to-date list of publications.
*denotes equal contribution
^denotes mentored undergraduate
Preprints
Kyriazis, CC, Grosser, S, Foster, Y, Masuda, B, Flanagan, AM, Balacco, J, Datlof, E, Fedrigo, O, Formenti, G, Grueber, CE, Robinson, JA, Sutton, JT, Tracey, A, Wood, JMD, Jarvis, ED, Ryder, OA, Robertson, BC & AP Wilder. 2026. Elevated recessive lethal frequencies drive hatching failure following near extinction in 'Alalā, the Hawaiian crow. bioRxiv: https://doi.org/10.64898/2026.03.24.713968
Lin, M, Chakraborty, S, Amorim, CEG, Nigenda-Morales, SF, Beichman, AC, Nuñez-Valencia, PG, Mah, J, Robinson, JA, Kyriazis, CC, Huber, CD, Webb, AE, Kocher, SD, Archer, FI, Moreno-Estrada, A, Wayne, RK & KE Lohmueller. 2025. The distribution of fitness effects varies phylogenetically across animals. bioRxiv. https://doi.org/10.1101/2025.05.13.653358
2025
Kyriazis, CC, Robinson, JA & KE Lohmueller. 2025. Long runs of homozygosity are reliable genomic markers of inbreeding depression. Trends in Ecology & Evolution, 40: 874-884. https://doi.org/10.1016/j.tree.2025.06.013
Kyriazis, CC, Venkatraman, M, Masuda, B, Steiner, CC, Cassin-Sackett, L, Crampton, LH, Flanagan, AM, Foster, JT, Houck, ML, Misuraca, AC, Paxton, EH, Robinson, JA, Fleischer, RC, Ryder, OA, Campana, MG & AP Wilder. Population genomics of recovery and extinction in Hawaiian honeycreepers. Current Biology, 35: 1-12. https://doi.org/10.1016/j.cub.2025.04.078
Media coverage: CNN, Hawai‘i Public Radio, Phys.org
Dispatch: Conservation genomics: Island birds on the brink
Gower, G*, Pope, NS*, Rodrigues, MR*, Tittes, S*, Tran, LN*, Alam, O, Cavassim, MIA, Fields, PD, Haller, BC, Huang, X, Jeffrey, B, Korfmann, K, Kyriazis, CC, Min, J, Rebollo, I, Rehmann, CT, Small, ST, Smith, CCR, Tsambos, G, Wong, Y, Zhang, Y, Huber, CD, Gorjanc, G, Ragsdale, AP, Gronau, I, Gutenkunst, RN, Kelleher, J, Lohmueller, KE, Schrider, DR, Ralph, PL & AD Kern. 2025. Accessible, realistic genome simulation with selection using stdpopsim. Molecular Biology and Evolution, 42:1-17 https://doi.org/10.1093/molbev/msaf236
Martinez i Zurita, A, Kyriazis, CC & KE Lohmueller. 2025. The impact of non-neutral synonymous mutations when inferring selection on non-synonymous mutations. Genetics, 231, iyaf200. https://doi.org/10.1093/genetics/iyaf200
2024
Kyriazis, CC & KE Lohmueller. 2024 Constraining models of dominance for nonsynonymous mutations in the human genome. PLoS Genetics, 20: e1011198. https://doi.org/10.1371/journal.pgen.1011198
Kyriazis, CC, Serieys, LEK, Bishop, JM, Drouilly, M, Viljoen, S, Wayne, RK & KE Lohmueller. 2024. The influence of gene flow on population viability in an isolated urban caracal population. Molecular Ecology, 33:1-20. https://doi.org/10.1111/mec.17346 [pdf]
2023
Kyriazis, CC, Robinson, JA, & KE Lohmueller. 2023. Using computational simulations to model deleterious variation and genetic load in natural populations. American Naturalist, 202:737-752. https://doi.org/10.1086/726736 [pdf]
Nigenda-Morales, SF*, Lin, M*, Nuñez-Valencia, PG, Kyriazis, CC, Beichman, AC, Robinson, JA, Ragsdale, AP, Urbán, J, Archer, FI, Viloria-Gómora, L, Pérez-Álvarez, MJ, Poulin, E, Lohmueller, KE, Moreno-Estrada, A & RK Wayne. 2023. The genomic footprint of whaling and isolation in fin whale populations. Nature Communications, 14:5465. https://doi.org/10.1038/s41467-023-40052-z [pdf]
Wade, EE*^, Kyriazis, CC*, Cavassim, MIA* & KE Lohmueller. 2023. Quantifying the fraction of new mutations that are recessive lethal. Evolution, 77:1539-1549. https://doi.org/10.1093/evolut/qpad061 [pdf]
Digest: Few mutations are recessive lethal
Kyriazis, CC, Robinson, JA, Nigenda-Morales, SF, Beichman, AB, Rojas-Bracho, L, Fontaine, M, Robertson, KM, Wayne, RK, Lohmueller, KE, Taylor, BL, & PA Morin. 2023. Models based on best-available information support a low inbreeding load and potential for recovery in the vaquita. Heredity, 130:183-187. https://doi.org/10.1038/s41437-023-00608-7 [pdf]
Kyriazis, CC, Beichman, AB, Brzeski, KE, Hoy, SR, Peterson, RO, Vucetch, JA, Vucetch, LM, Lohmueller, KE & RK Wayne. 2023. Genomic underpinnings of population persistence in Isle Royale moose. Molecular Biology and Evolution, 40, 1-17. https://doi.org/10.1093/molbev/msad021 [pdf]
Robinson, JA, Kyriazis, CC, Yuan, SC, & KE Lohmueller. 2023. Deleterious Variation in Natural Populations and Implications for Conservation Genetics. Annual Reviews of Animal Biosciences, 11, 93-114. https://doi.org/10.1146/annurev-animal-080522-093311 [pdf]
Beichman, AC, Kalhori, P, Kyriazis, CC, DeVries, AA, Nigenda-Morales, S, Koepfli, K, Heckel, G, Schramm, Y, Moreno-Estrada, A, Kennett, DJ, Hylkema, M, Bodkin, J, Lohmueller, KE, & RK Wayne. 2023. Genomic analyses reveal range-wide devastation of sea otter populations. Molecular Ecology, 32, 281-298. https://doi.org/10.1111/mec.16334 [pdf]
2022
Exposito-Alonso, M, Booker, TA, Czech, L, Fukami, T, Gillespie, L, Hateley, S, Kyriazis, CC, Lang, PLM, Leventhal, L, Nogues-Bravo, D, Pagowski, V, Ruffley, M, Spence, JP, Toro Arana, SE, Weiß, CL, & E Zess. 2022. Genetic diversity loss in the Anthropocene. Science, 377, 1431–1435. DOI: 10.1126/science.abn5642 [pdf]
Robinson, JA*, Kyriazis, CC*, Nigenda-Morales, SF, Beichman, AB, Rojas-Bracho, L, Fontaine, M, Robertson, KM, Wayne, RK, Lohmueller, KE, Taylor, BL, & PA Morin. 2022. The critically endangered vaquita is not doomed to extinction by inbreeding depression. Science, 376, 635-639. DOI: 10.1126/science.abm1742 [pdf]
Media coverage: CNN, NPR, NYT, Washington Post, National Geographic, BBC, CBC, Reuters, The Guardian, Gizmodo, New Scientist, Ars Technica
2021
Kyriazis, CC, Wayne, RK, & KE Lohmueller. 2021. Strongly deleterious mutations are a primary determinant of extinction risk due to inbreeding depression. Evolution Letters, 5, 33-47. https://doi.org/10.1002/evl3.209 [pdf]
Media coverage: The Atlantic, Science Magazine
2020
Adrion, JR*, Cole, CB*, Dukler, ND*, Galloway, JG*, Gladstein, AL*, Gower, G*, Kyriazis, CC*, Ragsdale, AR*, Tsambos, G*, Baumdicker, F, Carlson, J, Cartwright, RA, Durvasula, A, Gronau, I, Kim, BY, McKenzie, P, Messer, PW, Noskova, E, Ortega-Del Vecchyo, D, Racimo, F, Struck, TJ, Gravel, S, Gutenkunst, RN, Lohmueller, KE, Ralph, PL, Schrider, DR, Siepel, A, Kelleher, J, & AD Kern. 2020. A community-maintained standard library of population genetic models. eLife, 9:e54967. https://doi.org/10.7554/eLife.54967 [pdf]
Media coverage: Nature Methods
pre-2019
Heaney, LR*, Kyriazis, CC*, Balete, DS, Rickart, EA & SJ Steppan. 2018. How small an island? Speciation by endemic mammals on an oceanic Philippine island. Journal of Biogeography, 45, 1675-1687. [pdf]
Media coverage: Science Magazine, Nature, Mongabay
Kyriazis, CC, Alam, B, Wjodyla, M, Hosner, PA, Hackett, SJ, Mays Jr., HL., Heaney, LR & S Reddy. 2018. Colonization and diversification of the White-browed Shortwing in the Philippines. Molecular Phylogenetics and Evolution, 121, 121-131. [pdf]
Kyriazis, CC, Bates, JM & LR Heaney. 2017. Dynamics of genetic and morphological diversification in an incipient intra-island radiation of Philippine rodents (Muridae: Bullimus). Journal of Biogeography, 44, 2585-2594.
*denotes equal contribution
^denotes mentored undergraduate
Preprints
Kyriazis, CC, Grosser, S, Foster, Y, Masuda, B, Flanagan, AM, Balacco, J, Datlof, E, Fedrigo, O, Formenti, G, Grueber, CE, Robinson, JA, Sutton, JT, Tracey, A, Wood, JMD, Jarvis, ED, Ryder, OA, Robertson, BC & AP Wilder. 2026. Elevated recessive lethal frequencies drive hatching failure following near extinction in 'Alalā, the Hawaiian crow. bioRxiv: https://doi.org/10.64898/2026.03.24.713968
Lin, M, Chakraborty, S, Amorim, CEG, Nigenda-Morales, SF, Beichman, AC, Nuñez-Valencia, PG, Mah, J, Robinson, JA, Kyriazis, CC, Huber, CD, Webb, AE, Kocher, SD, Archer, FI, Moreno-Estrada, A, Wayne, RK & KE Lohmueller. 2025. The distribution of fitness effects varies phylogenetically across animals. bioRxiv. https://doi.org/10.1101/2025.05.13.653358
2025
Kyriazis, CC, Robinson, JA & KE Lohmueller. 2025. Long runs of homozygosity are reliable genomic markers of inbreeding depression. Trends in Ecology & Evolution, 40: 874-884. https://doi.org/10.1016/j.tree.2025.06.013
Kyriazis, CC, Venkatraman, M, Masuda, B, Steiner, CC, Cassin-Sackett, L, Crampton, LH, Flanagan, AM, Foster, JT, Houck, ML, Misuraca, AC, Paxton, EH, Robinson, JA, Fleischer, RC, Ryder, OA, Campana, MG & AP Wilder. Population genomics of recovery and extinction in Hawaiian honeycreepers. Current Biology, 35: 1-12. https://doi.org/10.1016/j.cub.2025.04.078
Media coverage: CNN, Hawai‘i Public Radio, Phys.org
Dispatch: Conservation genomics: Island birds on the brink
Gower, G*, Pope, NS*, Rodrigues, MR*, Tittes, S*, Tran, LN*, Alam, O, Cavassim, MIA, Fields, PD, Haller, BC, Huang, X, Jeffrey, B, Korfmann, K, Kyriazis, CC, Min, J, Rebollo, I, Rehmann, CT, Small, ST, Smith, CCR, Tsambos, G, Wong, Y, Zhang, Y, Huber, CD, Gorjanc, G, Ragsdale, AP, Gronau, I, Gutenkunst, RN, Kelleher, J, Lohmueller, KE, Schrider, DR, Ralph, PL & AD Kern. 2025. Accessible, realistic genome simulation with selection using stdpopsim. Molecular Biology and Evolution, 42:1-17 https://doi.org/10.1093/molbev/msaf236
Martinez i Zurita, A, Kyriazis, CC & KE Lohmueller. 2025. The impact of non-neutral synonymous mutations when inferring selection on non-synonymous mutations. Genetics, 231, iyaf200. https://doi.org/10.1093/genetics/iyaf200
2024
Kyriazis, CC & KE Lohmueller. 2024 Constraining models of dominance for nonsynonymous mutations in the human genome. PLoS Genetics, 20: e1011198. https://doi.org/10.1371/journal.pgen.1011198
Kyriazis, CC, Serieys, LEK, Bishop, JM, Drouilly, M, Viljoen, S, Wayne, RK & KE Lohmueller. 2024. The influence of gene flow on population viability in an isolated urban caracal population. Molecular Ecology, 33:1-20. https://doi.org/10.1111/mec.17346 [pdf]
2023
Kyriazis, CC, Robinson, JA, & KE Lohmueller. 2023. Using computational simulations to model deleterious variation and genetic load in natural populations. American Naturalist, 202:737-752. https://doi.org/10.1086/726736 [pdf]
Nigenda-Morales, SF*, Lin, M*, Nuñez-Valencia, PG, Kyriazis, CC, Beichman, AC, Robinson, JA, Ragsdale, AP, Urbán, J, Archer, FI, Viloria-Gómora, L, Pérez-Álvarez, MJ, Poulin, E, Lohmueller, KE, Moreno-Estrada, A & RK Wayne. 2023. The genomic footprint of whaling and isolation in fin whale populations. Nature Communications, 14:5465. https://doi.org/10.1038/s41467-023-40052-z [pdf]
Wade, EE*^, Kyriazis, CC*, Cavassim, MIA* & KE Lohmueller. 2023. Quantifying the fraction of new mutations that are recessive lethal. Evolution, 77:1539-1549. https://doi.org/10.1093/evolut/qpad061 [pdf]
Digest: Few mutations are recessive lethal
Kyriazis, CC, Robinson, JA, Nigenda-Morales, SF, Beichman, AB, Rojas-Bracho, L, Fontaine, M, Robertson, KM, Wayne, RK, Lohmueller, KE, Taylor, BL, & PA Morin. 2023. Models based on best-available information support a low inbreeding load and potential for recovery in the vaquita. Heredity, 130:183-187. https://doi.org/10.1038/s41437-023-00608-7 [pdf]
Kyriazis, CC, Beichman, AB, Brzeski, KE, Hoy, SR, Peterson, RO, Vucetch, JA, Vucetch, LM, Lohmueller, KE & RK Wayne. 2023. Genomic underpinnings of population persistence in Isle Royale moose. Molecular Biology and Evolution, 40, 1-17. https://doi.org/10.1093/molbev/msad021 [pdf]
Robinson, JA, Kyriazis, CC, Yuan, SC, & KE Lohmueller. 2023. Deleterious Variation in Natural Populations and Implications for Conservation Genetics. Annual Reviews of Animal Biosciences, 11, 93-114. https://doi.org/10.1146/annurev-animal-080522-093311 [pdf]
Beichman, AC, Kalhori, P, Kyriazis, CC, DeVries, AA, Nigenda-Morales, S, Koepfli, K, Heckel, G, Schramm, Y, Moreno-Estrada, A, Kennett, DJ, Hylkema, M, Bodkin, J, Lohmueller, KE, & RK Wayne. 2023. Genomic analyses reveal range-wide devastation of sea otter populations. Molecular Ecology, 32, 281-298. https://doi.org/10.1111/mec.16334 [pdf]
2022
Exposito-Alonso, M, Booker, TA, Czech, L, Fukami, T, Gillespie, L, Hateley, S, Kyriazis, CC, Lang, PLM, Leventhal, L, Nogues-Bravo, D, Pagowski, V, Ruffley, M, Spence, JP, Toro Arana, SE, Weiß, CL, & E Zess. 2022. Genetic diversity loss in the Anthropocene. Science, 377, 1431–1435. DOI: 10.1126/science.abn5642 [pdf]
Robinson, JA*, Kyriazis, CC*, Nigenda-Morales, SF, Beichman, AB, Rojas-Bracho, L, Fontaine, M, Robertson, KM, Wayne, RK, Lohmueller, KE, Taylor, BL, & PA Morin. 2022. The critically endangered vaquita is not doomed to extinction by inbreeding depression. Science, 376, 635-639. DOI: 10.1126/science.abm1742 [pdf]
Media coverage: CNN, NPR, NYT, Washington Post, National Geographic, BBC, CBC, Reuters, The Guardian, Gizmodo, New Scientist, Ars Technica
2021
Kyriazis, CC, Wayne, RK, & KE Lohmueller. 2021. Strongly deleterious mutations are a primary determinant of extinction risk due to inbreeding depression. Evolution Letters, 5, 33-47. https://doi.org/10.1002/evl3.209 [pdf]
Media coverage: The Atlantic, Science Magazine
2020
Adrion, JR*, Cole, CB*, Dukler, ND*, Galloway, JG*, Gladstein, AL*, Gower, G*, Kyriazis, CC*, Ragsdale, AR*, Tsambos, G*, Baumdicker, F, Carlson, J, Cartwright, RA, Durvasula, A, Gronau, I, Kim, BY, McKenzie, P, Messer, PW, Noskova, E, Ortega-Del Vecchyo, D, Racimo, F, Struck, TJ, Gravel, S, Gutenkunst, RN, Lohmueller, KE, Ralph, PL, Schrider, DR, Siepel, A, Kelleher, J, & AD Kern. 2020. A community-maintained standard library of population genetic models. eLife, 9:e54967. https://doi.org/10.7554/eLife.54967 [pdf]
Media coverage: Nature Methods
pre-2019
Heaney, LR*, Kyriazis, CC*, Balete, DS, Rickart, EA & SJ Steppan. 2018. How small an island? Speciation by endemic mammals on an oceanic Philippine island. Journal of Biogeography, 45, 1675-1687. [pdf]
Media coverage: Science Magazine, Nature, Mongabay
Kyriazis, CC, Alam, B, Wjodyla, M, Hosner, PA, Hackett, SJ, Mays Jr., HL., Heaney, LR & S Reddy. 2018. Colonization and diversification of the White-browed Shortwing in the Philippines. Molecular Phylogenetics and Evolution, 121, 121-131. [pdf]
Kyriazis, CC, Bates, JM & LR Heaney. 2017. Dynamics of genetic and morphological diversification in an incipient intra-island radiation of Philippine rodents (Muridae: Bullimus). Journal of Biogeography, 44, 2585-2594.
